CPTR required curriculum

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CPTR required 16-credit curriculum:  The CPTR has a competency-based curriculum that requires 15 core and 1 or more elective credits.

MSCR 761 Introduction to Clinical and Translational Research [CTR] (2 credits)
The national mandate to enhance the quality and quantity of clinical research inspired the development of the MSCR program to help beginning investigators gain knowledge and facility with appropriate scientific methodology for clinical and translational research. This course is designed as an introduction to the range of skills needed to make the appropriate choices in designing and carrying out clinical studies.

CPTR 500 Fundamentals of Epidemiology (2 credits)
This course introduces the principles and methods of epidemiology; it also will include concepts and methods used for population-based research. Epidemiologic study designs and data collection methods are described as well as approaches to data analyses. The concepts of bias and confounding are explored with examples from the clinical epidemiology literature. 

MSCR 591 Community Engagement and Health Disparities in Clinical and Translational Research (1 credit)
Led by Emory University (EU) and Morehouse School of Medicine (MSM) faculty, this course is an introduction to the concepts, methods, and issues involved in community engaged research with communities. Special emphasis is given to social and behavioral science concepts and methods; principles and historical roots of community engagement; clinical and translational research partnerships, multidisciplinary research collaborations; ethical issues; and practical considerations in planning, implementing, evaluating, and disseminating community-engaged research. Case studies and course projects are shaped to accommodate students with diverse interests in health disparities, communities, and/or translational research. Students are assumed to have a general research and clinical background, but the course emphasizes research theory and concepts with a goal to encourage thoughtful and effective community-based research collaborations.

MSCR 595 Health Services Research (1 credit)
This course provides students with an understanding of the nature, methods, scope, magnitude, and impact of Health Services Research (HSR). Students gain a better appreciation for the importance and relevance of HSR in improving healthcare delivery as well as key tools employed in HSR and areas of funding. Classes are designed to demonstrate the broad scope and multi-disciplinary nature of HSR by providing lectures from experts on a wide variety of topics that also provide practical examples of HSR.

CPTR 501 Translation to Clinical Medicine (2 credits)
The Translation to Clinical Medicine course provides non-clinicians (e.g., PhD graduate students or those with a PhD degree) with a new set of experiences relevant to both their understanding of disease and their research interest(s). CPTR 501 illuminates the impact of high quality translational research on clinical outcomes of patients with disease and how discoveries can be translated from the laboratory to the bedside and into the community.  The course director is Vin Tangpricha, MD, PhD, Associate Professor of Medicine at Emory.  Dr. Tangpricha meets with each CPTR trainee upon enrollment into the program and designs a rotation plan based on individual training needs.  Trainees are linked with a funded physician-scientist working in their area of discipline who helps them navigate through the clinical enterprise (e.g., a trainee interested in neuroscience research may round with Neurology inpatient consult teams and observe outpatient clinic visits).  A series of didactic lectures on fundamentals of working with research subjects and a simulated informed consent process are also presented to the cohort.  Those with a clinical background (e.g., RN, MD or PharmD) may take an additional formal elective course in lieu of CPTR 501, or can fashion a personalized 2-credit elective experience that may include alternative mentored training related to clinical disorders relevant to their research needs, that may include, for example hands-on bench training (e.g. flow cytometry, genomics, transcriptionomics, epigenetics, proteomics and/or metabolomics). 

CPTR 502 Biostatistics for Translational Research (2 credits)
This course introduces statistical concepts and analytical methods with special attention to data encountered in the biomedical sciences and biotechnology as well as translational research. It emphasizes the basic concepts of study design including clinical trials, quantitative analysis of data, probability, and statistical inferences.

MSCR 592 Clinical Research Colloquium (1 credit)
Seminar-style course that covers a wide array of practical issues in CTR including: research administration and grants management; federal funding process; IRB and HIPAA; Conflict of Interests; Legal Aspects of Translational Research; Drug Discovery; Industry interactions (drug discovery and device development); Multidisciplinary research and Team Science; Mentor and mentee training; Translational Research Informatics, Health Services and Implementation Science Research

MSCR 593 Ethical, Legal, and Social Issues of Responsible Clinical and Translational Research (1 credit)
This course prepares students to engage in theoretically and practically based discourse and decision making in ethical issues involved in clinical and biomedical research.   The course will survey a variety of ethical issues occurring in basic and applied research settings and analyze approaches that seek to prevent or resolve them. Classes will primarily consist of the faculty and students leading discussions around various articles and case studies.

MSCR 594A&B Scientific and Grant Writing (2 credits)
The goal of this class is to help you become an excellent grant writer. Some students will work on grant proposals that will be submitted to funding agencies such as the NIH while others will write a ‘practice’ grant proposal that will be of the quality of an actual competitive grant proposal. The final product for this course is a grant proposal with all the required components outlined in the table below. You will receive feedback from the instructors on all your writing throughout the course. Certificate students may submit a pure cell and/or animal-based research grant proposal, but it must include details on the translational significance of the proposed work for potential human investigation. Certificate students may also submit a proposal that includes human subject research as part of or as the entire proposal, if they choose. MSCR students MUST submit a grant proposal that includes human subject research as part of or as the entire proposal. The grant may thus also include cell/animal research components. NIH defines translational/human subject research as studies involving data derived from identifiable human subjects, and thus can include databases, blood/tissue biobank material, work with cells isolated from identifiable humans, including primary culture, etc. The grant proposal cannot be based solely on work with human cell lines or animal model/primate research.

MSCR 597 Big Data to Knowledge (BD2K) in CTR Research (1 credit)
The course will teach and expose students to fundamental data workflow principles universal to application of big data science in CTR.  The elements of this workflow comprise the Big Data Pipeline and concern the generation, acquisition, processing, analysis, and presentation of Big Data.  The application of this workflow will be taught through three extended case studies in the fields of clinical health informatics (electronic medical records), public health informatics, and “omics” with three corresponding projects to engage students in the acquisition and organization of data.

ELECTIVES (1-2-credit)
A 1-2 credit elective is required and may be taken at any of the ACTSI institutions upon approval of the ACTSI Research Education Executive Committee. 

MSCR 596 Advanced Data Management in R – ELECTIVE – NOT REQUIRED (2 credits)
This course prepares students to engage in theoretically and practically based discourse and decision making in ethical issues involved in clinical and biomedical research.   The course will survey a variety of ethical issues occurring in basic and applied research settings and analyze approaches that seek to prevent or resolve them. Classes will primarily consist of the faculty and students leading discussions around various articles and case studies.

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